A clinical trial to look at the long-term safety of faricimab in patients with neovascular age‑related macular degeneration (nAMD, also known as wet AMD)

A Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

  • Eye Disorder
  • Neovascular Age-related Macular Degeneration
  • Wet Age‑Related Macular Degeneration
  • Age-Related Macular Degeneration
Please note that the recruitment status of the study at your site may differ from the overall study status because some study sites may recruit earlier than others.
Study Status:

Completed

This study runs in
Cities
  • aan
  • Abilene
  • Aiea
  • Albury
  • Amagasaki
  • Ankara
  • Asahikawa
  • Augusta
  • Austin
  • Baltimore
  • Barcelona
  • Beachwood
  • Bielsko-Biała
  • Binningen
  • Boisbriand
  • Boston
  • Bradford
  • Bristol
  • Budapest
  • Buenos Aires
  • Burjasot
  • Busan
  • Bydgoszcz
  • Bytom
  • Calgary
  • Camberley
  • Campbell
  • Cardiff
  • Changhua County
  • Charlotte
  • Chattanooga
  • Cheboksary
  • Chesterfield
  • Chevy Chase
  • Chiba
  • Chicago
  • Chiyoda City
  • Cincinnati
  • Ciudad de México
  • Coimbra
  • Colorado Springs
  • Columbus
  • Créteil
  • czelad_
  • Daegu
  • Dallas
  • Debrecen
  • Dublin
  • Düsseldorf
  • East Melbourne
  • Edina
  • Edison
  • Florissant
  • Fort Lauderdale
  • Freiburg im Breisgau
  • Fukuoka
  • Fukushima
  • Gdańsk
  • Germantown
  • Glendora
  • Glostrup
  • Gloucester
  • Goiás
  • Grand Rapids
  • Graz
  • Hachioji
  • Hagerstown
  • Haifa
  • Harlingen
  • Hauppauge
  • Heidelberg
  • Hickory
  • Hirakata
  • Hong Kong Island
  • Hull
  • Ichinomiya
  • Iida
  • Indianapolis
  • İzmir
  • Kagoshima
  • Kashihara
  • Kazan
  • Kocaeli
  • Kraków
  • Kumamoto
  • Kurume
  • Kyoto
  • Köln
  • L'Hospitalet de Llobregat
  • Ladson
  • Lakewood
  • Leeds
  • Lenexa
  • liverpool
  • Liverpool
  • Lombardy
  • London
  • Long Beach
  • Los Angeles
  • Lynchburg
  • Lyon
  • Madrid
  • Majadahonda
  • Manchester
  • Marseille
  • Matsumoto
  • Melbourne
  • Mendoza
  • Mesa
  • Miki
  • Milano
  • Millcreek
  • Mitaka
  • Mito
  • Miyazaki
  • Monterrey
  • Moriguchi
  • Moskva
  • Mountain View
  • Münster
  • Nagakute
  • Nagasaki
  • Nantes
  • Nashville
  • Nedlands
  • Newcastle upon Tyne
  • Nishihara
  • Nishinomiya
  • Norfolk
  • Novosibirsk
  • Oak Forest
  • Oceanside
  • Osaka
  • Otsu
  • Ottawa
  • Oviedo
  • Palm Beach Gardens
  • Palm Desert
  • Pamplona
  • Paris
  • Parramatta
  • Pennsylvania
  • Pensacola
  • Perugia
  • Petah Tikva
  • Philadelphia
  • Phoenix
  • Pisa
  • Plantation
  • Pompano Beach
  • Portland
  • Porto
  • Poway
  • Pécs
  • Rapid City
  • Redlands
  • Rehovot
  • Reno
  • Rochester
  • Roma
  • Rosario
  • Roskilde
  • Rotterdam
  • Rowville
  • Sacramento
  • Saint Petersburg
  • Sakura
  • Salt Lake City
  • Sankt-Peterburg
  • Sant Cugat del Vallès
  • Santa Ana
  • Santa Barbara
  • Santiago de Compostela
  • Sapporo
  • Seongnam-si
  • Seoul
  • shenandoah
  • Sherbrooke
  • Shinjuku City
  • Shirley
  • Silverdale
  • Singapore
  • Slingerlands
  • Sofia
  • Southampton
  • Southlake
  • Springfield
  • St. Petersburg
  • Strathfield
  • Sydney
  • Szeged
  • São Paulo
  • Taipei City
  • Tallahassee
  • Tampa
  • Taoyuan City
  • Tarnowskie Góry
  • Teaneck
  • Tel Aviv-Yafo
  • The Woodlands
  • Tokorozawa
  • Toronto
  • Towson
  • Tsu
  • Tucson
  • Ube
  • Valladolid
  • Vancouver
  • Waterford
  • West Des Moines
  • west-columbia
  • Wien
  • Willow Park
  • Wolverhampton
  • Wrocław
  • York
  • Zalaegerszeg
  • Zaragoza
  • Écully
  • 横浜市
Trial Identifier:

NCT04777201 2020-004523-16 GR42691

  • ?Intersec Research and Technology Complex Eye Microsurgery n a Fyodorov Novosibirsk Branch

    149 Ulitsa L'va Tolstogo630008NovosibirskRussia
  • 1 Saint-Petersburg St. Med. University named after academician I.P.Pavlov; Chair of ophathalmology

    197022Saint PetersburgRussia
  • Aichi Medical University Hospital

    480-1195NagakuteJapan
  • Ankara Baskent University Medical Faculty; Department of Ophthalmology

    06490AnkaraTürkiye
  • Ankara University Medical Faculty; Department of Ophthalmology

    06340
  • Arizona Retina and Vitreous Consultants

    3840 N 16th St85016PhoenixUnited States
  • Asahikawa Medical University Hospital

    078-8510AsahikawaJapan
  • Asan Medical Center

    05505SeoulSouth Korea
  • Associated Retina Consultants

    1750 E Glendale Ave85020PhoenixUnited States
  • Associated Retinal Consultants

    1179 E Paris Ave SE49546Grand RapidsUnited States
  • ASST FATEBENEFRATELLI SACCO; Oculistica (Sacco)

    20157LombardyItaly
  • Augenabteilung am St. Franziskus-Hospital

    74 Hohenzollernring48145MünsterGermany
  • Austin Clinical Research LLC

    9707 Anderson Mill Rd78750AustinUnited States
  • Austin Retina Associates

    78705-1169AustinUnited States
  • Azienda Ospedaliera di Perugia Ospedale S. Maria Della Misericordia; Clinica Oculistica

    3 Piazzale Giorgio Menghini06129PerugiaItaly
  • Bajcsy-Zsilinszky Hospital

    89-91 Maglódi út1106BudapestHungary
  • Barnet Dulaney Perkins Eye Center

    5250 E Southern Ave85206MesaUnited States
  • Black Hills Eye Institute

    57701Rapid CityUnited States
  • Bristol Eye Hospital;Retinal Treatment and Research Unit

    BS1 2LXBristolUnited Kingdom
  • Budapest Retina Associates Kft.

    76 Váci út1133BudapestHungary
  • Buenos Aires Mácula

    C1061AAEBuenos AiresArgentina
  • Calgary Retina Consultants

    5340 1 St SWT2H 0C8CalgaryCanada
  • California Eye Specialists Medical group Inc.

    150 S Grand Ave91741GlendoraUnited States
  • California Retina Consultants

    525 E Micheltorena St93103Santa BarbaraUnited States
  • Caminomed

    3 Wyszyńskiego42-600Tarnowskie GóryPoland
  • Centre For Eye Research Australia

    200 Victoria Parade3002East MelbourneAustralia
  • Centre Paradis Monticelli; Ophtalmologie

    433 Rue Paradis13008MarseilleFrance
  • Centro Hospitalar E Universitário de Coimbra EPE - Serviço Oftalmologia; Serviço Oftalmologia

    3004-561CoimbraPortugal
  • Centro Oftalmológico Dr. Charles S.A.

    C1015ABOBuenos AiresArgentina
  • Centro Oftalmológico Mira, S.C

    #35 C. Taxco06760Ciudad de MéxicoMexico
  • Centrum Medyczne Dietla 19 Sp. Z O.O.

    19 Józefa Dietla31-070KrakówPoland
  • Chang Gung Medical Foundation - Linkou; Ophthalmology

    259號 Wenhua 1st Rd333Taoyuan CityTaiwan
  • Changhua Christian Hospital; Department of Ophthalmology

    176 Zhonghua Rd500Changhua CountyTaiwan
  • Char Eye Ear &Throat Assoc

    28210CharlotteUnited States
  • Charles Retina Institute

    1432 Kimbrough Rd38138GermantownUnited States
  • Charleston Neuroscience Inst

    9551 US-7829456LadsonUnited States
  • Chi De Creteil; Ophtalmologie

    40 Av. de Verdun94000CréteilFrance
  • Chiba University Hospital

    260-8677ChibaJapan
  • CHU Nantes - Hôtel Dieu; Ophthalmology

    1 Pl. Alexis-Ricordeau44000NantesFrance
  • Cincinnati Eye Institute

    45242CincinnatiUnited States
  • Clinica Baviera; Servicio Oftalmologia

    20 P.º de la Castellana28046MadridSpain
  • Clinica Universitaria de Navarra; Servicio de Oftalmologia

    36 Av. de Pío XII31008PamplonaSpain
  • Clinics of Eye Diseases, LLC

    420066KazanRussia
  • Colorado Retina Associates, PC

    255 S Routt Way80228LakewoodUnited States
  • Cumberland Valley Retina PC

    1800 Dual Hwy21740HagerstownUnited States
  • Daiyukai Daiichi Hospital

    491-0025IchinomiyaJapan
  • Debreceni Egyetem Klinikai Kozpont; Szemeszeti Klinika

    98 Nagyerdei krt.4032DebrecenHungary
  • Dobry Wzrok Sp Z O O

    3 Karwieńska80-328
  • Ege University Medical Faculty; Department of Ophthalmology

    35100İzmirTürkiye
  • Eszak-Pesti Centrumkorhaz - Honvedkorhaz; Szemeszet

    44 Róbert Károly körút1134BudapestHungary
  • Eyeclinic Albury Wodonga

    669 Dean St2640AlburyAustralia
  • Florida Eye Associates

    32901MelbourneUnited States
  • Fondazione G.B. Bietti Per Lo Studio E La Ricerca in Oftalmologia-Presidio Ospedaliero Britannico

    6 Via Santo Stefano Rotondo00184RomaItaly
  • Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico-Clinica Regina Elena;U.O.C Oculistica

    6 Via Manfredo Fanti20122MilanoItaly
  • Fort Lauderdale Eye Institute

    850 S Pine Island Rd33324PlantationUnited States
  • Frimley Park Hospital

    GU16 7UJCamberleyUnited Kingdom
  • FSBI ?Scientific Research Institute of Eye Diseases? of Russian Academy of medical Sciences

    11А Ulitsa Rossolimo119021MoskvaRussia
  • Fukushima Medical University Hospital

    960-1295FukushimaJapan
  • Fundacion Zambrano

    1023Buenos AiresArgentina
  • Gabinet Okulistyczny Prof Edward Wylegala

    8 Rynek40-003czelad_Poland
  • Ganglion Medial Center

    7621PécsHungary
  • Gazi University Faculty of Medicine; Department Of Ophthalmology

    37 Dögol Cd.06570AnkaraTürkiye
  • Georgia Retina PC

    30060-1137
  • Gloucestershire Hospitals NHS Foundation Trust

    GL1 2ELGloucesterUnited Kingdom
  • Graystone Eye

    2424 Century Pl SE28602HickoryUnited States
  • Grupo Laser Vision

    S2000DLARosarioArgentina
  • Hacettepe University Medical Faculty; Department of Ophthalmology

    06100AnkaraTürkiye
  • Hayashi Eye Hospital

    812-0011FukuokaJapan
  • Het Oogziekenhuis Rotterdam

    180 Schiedamse Vest3011 BHRotterdamNetherlands
  • Hong Kong Eye Hospital; CUHK Eye Centre

    147K Argyle StTorontoHong Kong
  • Hopital de la croix rousse; Ophtalmologie

    103 Gd Rue de la Croix-Rousse69004LyonFrance
  • Hopital Lariboisiere; Ophtalmologie

    2 Rue Ambroise Paré75010ParisFrance
  • Hospital Clinic de Barcelona; Consultas Externas Oftalmologia

    170 Carrer de Villarroel08036BarcelonaSpain
  • Hospital de Olhos de Aparecida - HOA

    S/n Av. Dom Abel Ribeiro74980-010GoiásBrazil
  • Hospital de Sao Joao; Servico de Oftalmologia

    4200-319PortoPortugal
  • Hospital dos de maig; servicio de oftalmologia

    301 Carrer del dos de Maig08025BarcelonaSpain
  • Hospital General de Catalunya

    1 Carrer de Pedro i Pons08195Sant Cugat del VallèsSpain
  • Hospital Universitario de Bellvitge

    s/n Carrer de la Feixa Llarga08907L'Hospitalet de LlobregatSpain
  • Hospital Universitario Miguel Servet; Servicio de Oftalmologia

    1-3 P.º de Isabel la Católica50009ZaragozaSpain
  • Hospital Universitario Puerta de Hierro

    1 C. Joaquín Rodrigo28222MajadahondaSpain
  • Hospital Universitario Rio Hortega; Servicio de Oftalmologia

    2 C. Dulzaina47012ValladolidSpain
  • Hull Royal Infirmary

    HU3 2JZHullUnited Kingdom
  • Hyogo Medical University Hospital

    663-8501NishinomiyaJapan
  • Hyogo Prefectural Amagasaki General Medical Center (Hyogo AGMC)

    660-8550AmagasakiJapan
  • Ideta Eye Hospital

    860-0027KumamotoJapan
  • Iida Municipal Hospital

    395-8502IidaJapan
  • Institut De L'Oeil Des Laurentides

    6110 R. Doris-LussierJ7H 0E8BoisbriandCanada
  • Institut de la Macula i la retina

    12 Carrer de Vilana08022BarcelonaSpain
  • Instituto Oftalmologico Fernandez Vega; Servicio de oftalmologia

    34 Av. Doctores Fernández Vega33012OviedoSpain
  • Instituto Oftalmologico Gomez Ulla; Servicio de Oftalmologia

    3 Rúa de Maruja Mallo15706Santiago de CompostelaSpain
  • Intersec Research and Technology Complex ?Eye Microsurgery? n.a. S.N. Fyodorov; Cheboksary Branch

    428000CheboksaryRussia
  • Island Retina

    60 Northern Blvd11967ShirleyUnited States
  • Ivey Eye Institute

    268 Grosvenor StN6A 4V2LondonCanada
  • Japanese Red Cross Nagasaki Genbaku Hospital

    852-8104NagasakiJapan
  • Johns Hopkins Med; Wilmer Eye Inst

    1800 Orleans St21287BaltimoreUnited States
  • Kagawa University Hospital

    761-0793MikiJapan
  • Kagoshima University Hospital

    890-0075KagoshimaJapan
  • Kansai Medical University Hospital

    573-1191HirakataJapan
  • Kansai Medical University Medical Center

    570-8507MoriguchiJapan
  • Kaplan Medical Center; Ophtalmology

    1 Derech Pasternak7660101RehovotIsrael
  • Kitano Hospital

    530-8480OsakaJapan
  • Kocaeli University Medical Faculty

    41001KocaeliTürkiye
  • Kozawa eye hospital and diabetes center

    310-0845MitoJapan
  • Kurume University Hospital

    830-0011KurumeJapan
  • Kyorin University Hospital

    181-8611MitakaJapan
  • Kyoto University Hospital

    606-8507KyotoJapan
  • Kyung Hee University Hospital

    130-050SeoulSouth Korea
  • LKH-Univ.Klinikum Graz; Universitäts-Augenklinik

    1 Auenbruggerpl.8036GrazAustria
  • Long Is. Vitreoretinal Consult

    200 Motor Pkwy11788HauppaugeUnited States
  • Macula Retina Consultores

    108 Calle Sur 13201120Ciudad de MéxicoMexico
  • Maine Eye Center

    161 Marginal Way04101PortlandUnited States
  • Manchester Royal Eye Hospital

    M13 9WLManchesterUnited Kingdom
  • Medical Military Academy n.a S.M.Kirov

    194044Sankt-PeterburgRussia
  • Medizinische Universität Wien; Universitätsklinik für Augenheilkunde und Optometrie

    18-20 Währinger Gürtel1090WienAustria
  • Michel Giunta Clinique Medical

    20 12e Avenue SJ1G 2V4SherbrookeCanada
  • Mid Atlantic Retina - Wills Eye Hospital

    840 Walnut St19107PhiladelphiaUnited States
  • Midwest Retina

    6655 Post Rd43016DublinUnited States
  • Midwest Vision Research Foundation

    1815 Clarkson Rd63017ChesterfieldUnited States
  • Mie University Hospital

    514-8507TsuJapan
  • Montemayor & Asociados (Oftalmologos)

    2709 Alpes64060MonterreyMexico
  • Moorfields Eye Hospital NHS Foundation Trust

    162 City RdEC1V 2PDLondonUnited Kingdom
  • Nagoya City University Hospital

    467-8602横浜市Japan
  • Nagoya University Hospital

    466-8560横浜市Japan
  • Nara Medical University Hospital

    634-8522KashiharaJapan
  • National Defense Medical College Hospital

    359-8513TokorozawaJapan
  • New Cross Hospital

    WV10 0QPWolverhamptonUnited Kingdom
  • Nihon University Hospital

    101-8309Chiyoda CityJapan
  • NJ Retina

    98 James St08820EdisonUnited States
  • Northern California Retina Vitreous Associates

    2495 Hospital Dr94040Mountain ViewUnited States
  • Northwestern Medical Group/Northwestern University

    676 N St Clair St60611ChicagoUnited States
  • Nune Eye Hospital; Ophthalmology

    06212SeoulSouth Korea
  • Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello; U.O. Oculistica Universitaria

    2 Via Paradisa56124PisaItaly
  • OFTALMIKA Sp. z o.o

    85-631BydgoszczPoland
  • Oftalmos

    1832 Av. CórdobaC1120aanArgentina
  • Oftalvist Valencia

    1 Av. de la Ilustración46100BurjasotSpain
  • Oftar

    M5500GGKMendozaArgentina
  • Ophthalmic Cons of Long Island

    11572OceansideUnited States
  • Ophthalmic Consultants of Boston

    50 Staniford St02114BostonUnited States
  • Opthalmology Research Office

    BD9 6RJBradfordUnited Kingdom
  • Optimum Profesorskie Centrum Okulistyki

    30 Cienista80-809GdańskPoland
  • Orange County Retina Med Group

    999 N Tustin Ave92705Santa AnaUnited States
  • Organizacion Medica de Investigacion

    725 UruguayC1015Buenos AiresArgentina
  • Osaka Metropolitan University Hospital

    545-0051OsakaJapan
  • Palmetto Retina Center

    124 Sunset Ct29169west-columbiaUnited States
  • Pentagram Eye Hospital (Medical Center "Pentagram")

    109 ul. "Vranya"1309SofiaBulgaria
  • Piedmont Eye Center

    116 Nationwide Dr24502LynchburgUnited States
  • Pole Vision Val d'Ouest; Ophtalmologie

    39 Chem. de la Vernique69130ÉcullyFrance
  • Prairie Retina Center

    2800 Montaluma Dr62704SpringfieldUnited States
  • Pusan National University Hospital

    602-739BusanSouth Korea
  • Queen Mary Hospital; Department of Ophthalmology

    Hong Kong IslandHong Kong
  • Rabin MC; Ophtalmology

    4941492Petah TikvaIsrael
  • Raj K. Maturi, MD PC

    10300 Illinois St46290IndianapolisUnited States
  • Rambam Medical Center; Opthalmology

    8 HaAliya HaShniya St3109601HaifaIsrael
  • Rand Eye

    5 W Sample Rd33064Pompano BeachUnited States
  • Retina Assoc of Cleveland Inc

    24075 Commerce Park Rd44122BeachwoodUnited States
  • Retina Assoc of Western NY

    160 Sawgrass Dr14620RochesterUnited States
  • Retina Associates

    8600 Quivira Rd66215LenexaUnited States
  • Retina Associates of Florida, LLC

    602 S MacDill Ave33609TampaUnited States
  • Retina Associates of NJ

    07666TeaneckUnited States
  • Retina Associates of St. Louis

    1224 Graham Rd63031FlorissantUnited States
  • Retina Associates of Utah, PLLC

    84107MillcreekUnited States
  • Retina Associates Southwest PC

    2121 N Craycroft Rd85712TucsonUnited States
  • Retina Care Specialists

    3399 PGA Boulevard33410Palm Beach GardensUnited States
  • Retina Center Northwest

    9800 Levin Rd NW98383SilverdaleUnited States
  • Retina Center of Texas

    305 Morrison Park Dr76092SouthlakeUnited States
  • Retina Consultants of Hawaii

    98-1079 Moanalua Rd96701AieaUnited States
  • Retina Consultants of Houston

    77384shenandoahUnited States
  • Retina Consultants of Southern

    2770 N Union Blvd80909Colorado SpringsUnited States
  • Retina Consultants of Southern California

    1895 Orange Tree Ln92374RedlandsUnited States
  • Retina Consultants of Texas

    17450 St Lukes Way77384The WoodlandsUnited States
  • Retina Consultants, San Diego

    12630 Monte Vista Rd92064PowayUnited States
  • Retina Group of Florida

    6333 N Federal Hwy33308Fort LauderdaleUnited States
  • Retina Group of New England

    174 Cross Rd06385WaterfordUnited States
  • Retina Group of Washington

    5454 Wisconsin Ave20815Chevy ChaseUnited States
  • Retina Northwest

    5440 SW Westgate Dr97221PortlandUnited States
  • Retina Res Institute of Texas

    79606AbileneUnited States
  • Retina Specialists

    6569 MD-13921204TowsonUnited States
  • Retina Specialists Victoria

    1091 Stud Rd3178RowvilleAustralia
  • Retina Specialty Institute

    5150 N Davis Hwy32503PensacolaUnited States
  • Retina Vit Surgeons/Central NY

    200 Greenfield Pkwy13088liverpoolUnited States
  • Retina Vitreous Assoc of FL

    4344 Central Ave33711St. PetersburgUnited States
  • Retinal Consultants Med Group

    5775 Greenback Ln95841SacramentoUnited States
  • Retinal Diagnostic Center

    3395 S Bascom Ave95008CampbellUnited States
  • Rigshospitalet Glostrup; Afdeling for Øjensygdomme, Center for Forskning

    13 Valdemar Hansens Vej2600GlostrupDenmark
  • Rocky Mountain Retina

    84107Salt Lake CityUnited States
  • Royal Liverpool University Hospital; St Paul's Clinical Eye Research Centre

    L7 8YELiverpoolUnited Kingdom
  • Royal Victoria Infirmary

    NE1 4LPNewcastle upon TyneUnited Kingdom
  • Samsung Medical Center

    06351SeoulSouth Korea
  • Sapporo City General Hospital

    060-8604SapporoJapan
  • Selcuk University Faculty of Medicine; Department Of Ophthalmology

    42250
  • Seoul National University Bundang Hospital

    463-707Seongnam-siSouth Korea
  • Seoul National University Hospital

    03080SeoulSouth Korea
  • Shiga University Of Medical Science Hospital

    520-2192OtsuJapan
  • Shinshu University Hospital

    390-0802MatsumotoJapan
  • Sierra Eye Associates

    950 Ryland St89502RenoUnited States
  • Singapore Eye Research Institute

    20 College Rd169856SingaporeSingapore
  • Sjællands Universitetshospital, Roskilde; Øjenafdelingen

    23 Vestermarksvej4000RoskildeDenmark
  • South Coast Retina Center

    4300 Long Beach Blvd90807Long BeachUnited States
  • Southeast Retina Center

    3685 Wheeler Rd30909AugustaUnited States
  • Southeastern Retina Associates Chattanooga

    1606 Gunbarrel Rd37421ChattanoogaUnited States
  • Southern CA Desert Retina Cons

    36949 Cook St92211Palm DesertUnited States
  • Southern Vitreoretinal Assoc

    2439 Care Dr32308TallahasseeUnited States
  • SP ZOZ Szpital Uniwersytecki w Krakowie Oddzia? Kliniczny Okulistyki i Onkologii Okulistycznej

    38 Mikołaja Kopernika31-501KrakówPoland
  • Specialized Hospital for Active Treatment of Eye Diseases Zora

    20 bul. „Andrej Sakharov“1000SofiaBulgaria
  • Specjalistyczny O?rodek Okulistyczny Oculomedica

    14 Górzyskowo85-157BydgoszczPoland
  • SPEKTRUM Osrodek Okulistyki Klinicznej

    4 Zaolziańska53-334WrocławPoland
  • St James University Hospital

    LS9 7TFLeedsUnited Kingdom
  • Strategic Clinical Research Group, LLC

    76087Willow ParkUnited States
  • Strathfield Retina Clinic

    9-13 Redmyre Rd2135StrathfieldAustralia
  • Sydney Eye Hospital

    8 Macquarie St2000SydneyAustralia
  • Sydney Retina Clinic and Day Surgery

    187 Macquarie St2000SydneyAustralia
  • Sydney West Retina

    10 Darcy St2150ParramattaAustralia
  • Szegedi Tudományegyetem ÁOK; Department of Ophtalmology

    10-11 Korányi fasor6720SzegedHungary
  • Szpital Specjalistyczny nr 1; Oddzial Okulistyki

    7 Stefana Żeromskiego41-902BytomPoland
  • Szpital sw. Lukasza

    94B Bystrzańska43-309Bielsko-BiałaPoland
  • Taipei Veterans General Hospital; Ophthalmology

    201號 Section 2, Shipai Rd112Taipei CityTaiwan
  • Tel Aviv Sourasky MC; Ophtalmology

    6 Weizmann St6423906Tel Aviv-YafoIsrael
  • Tennessee Retina PC.

    345 23rd Ave N37203NashvilleUnited States
  • Texas Retina Associates

    75231DallasUnited States
  • The Lions Eye Institute

    6009NedlandsAustralia
  • The Ohio State University Havener Eye Institute

    915 Olentangy River Rd43212ColumbusUnited States
  • The Retina Care Center

    6115 Falls Rd21209BaltimoreUnited States
  • The Retina Centre of Ottawa

    2211 Carling AveK2B 7E9OttawaCanada
  • The Retina Consultants

    1220 New Scotland Rd12159SlingerlandsUnited States
  • The Retina Partners

    16500 Ventura Blvd91436Los AngelesUnited States
  • The York Hospital

    YO31 8HEYorkUnited Kingdom
  • Toho University Sakura Medical Center

    285-0841SakuraJapan
  • Tokyo Medical University Hachioji Medical Center

    193-0998HachiojiJapan
  • Tokyo Women's Medical University Hospital

    162-8666Shinjuku CityJapan
  • Toronto Retina Institute

    6 Maginn MewsM3C 0G6TorontoCanada
  • Tufts Medical Center; Ophthalmology

    02116BostonUnited States
  • Universidade Federal de Sao Paulo - UNIFESP*X; Oftalmologia

    862 R. Botucatu04023-062São PauloBrazil
  • Universitätkslinikum Düsseldorf, Augenklinik; Klinik fürAugenheilkunde

    5 Moorenstraße40225DüsseldorfGermany
  • Universitätsklinik Heidelberg; Augenklinik

    400 Im Neuenheimer Feld69120HeidelbergGermany
  • Universitätsklinikum Freiburg, Klinik für Augenheilkunde

    5 Killianstraße79106Freiburg im BreisgauGermany
  • Universitätsklinikum Köln; Augenklinik

    62 Kerpener Str.50937KölnGermany
  • Universitätsklinikum Münster; Augenheilkunde

    15 Domagkstraße48149MünsterGermany
  • University Hospital of Wales

    CF14 4XWCardiffUnited Kingdom
  • University Hospital Southampton NHS Foundation Trust; Southampton Eye Unit

    103 Tremona RdSO16 6HUSouthamptonUnited Kingdom
  • University of British Columbia - Vancouver Coastal Health Authority

    2775 Laurel StV5Z 1M9VancouverCanada
  • University of California, Davis, Eye Center

    4860 Y St95817SacramentoUnited States
  • University of Miyazaki Hospital

    889-1601MiyazakiJapan
  • University of the Ryukyus Hospital

    903-0215NishiharaJapan
  • University Retina and Macula Associates, PC

    6320 W 159th St60452Oak ForestUnited States
  • Valley Retina Institute P.A.

    78550HarlingenUnited States
  • Vista Klinik Ophthalmologische Klinik

    4102BinningenSwitzerland
  • VitreoRetinal Surgery, PLLC.; DBA Retina Consultants of Minnesota

    3601 W 76th St55435EdinaUnited States
  • Wagner Kapoor Institute

    6160 Kempsville Cir23502NorfolkUnited States
  • Western Carolina Retinal Associate PA

    28803PennsylvaniaUnited States
  • Wolfe Eye Clinic

    50266West Des MoinesUnited States
  • Yamaguchi University Hospital

    755-0046UbeJapan
  • Yeungnam University Medical Center

    42415DaeguSouth Korea
  • Zala Megyei Kórház; SZEMESZET

    1 Zrínyi Miklós u.8900ZalaegerszegHungary
    Show study locations

    The source of the below information is public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc.. It has been summarised and edited into simpler language. For more information about this clinical study see the For Expert tab on the specific ForPatients page or follow these links to https://clinicaltrials.gov and/or https://euclinicaltrials.eu and/or https://www.isrctn.com.

    The below information is taken directly from public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc., and has not been edited.

    Results Disclaimer

    Study Summary

    This main long-term extension study is designed to evaluate the long-term safety and tolerability of faricimab 6 milligrams (mg) administered by intravitreal injection at a personalized treatment interval (PTI) to participants with neovascular age‑related macular degeneration (nAMD) who enrolled in and completed one of the Phase III studies: GR40306 (NCT03823287) or GR40844 (NCT03823300), also referred to as the parent studies. Eligible patients who consent to participate in this main study will be enrolled upon completion of the end-of-study visit in the parent study. Additionally, there is a substudy that is being conducted. The aim of this substudy is to evaluate the impact of intravitreal faricimab on the health of the corneal endothelial cells in the study eyes of patients with nAMD to fulfill a U.S. Food and Drug Administration (FDA) post-marketing requirement. The fellow eyes of the same enrolled participants in the substudy will serve as the controls.

    Hoffmann-La Roche Sponsor
    Phase 3 Phase
    NCT04777201, GR42691, 2020-004523-16 Study Identifier
    All Gender
    ≥50 Years Age
    No Healthy Volunteers

    How does the Avonelle-X (GR42691) clinical trial work?

    This clinical trial is recruiting people who have neovascular age-related macular degeneration (nAMD, also known as wet AMD) and who previously participated in and completed either Study GR40306 (also known as TENAYA) or GR40844 (also known as LUCERNE). 

    The purpose of this clinical trial is to learn more about the effects, good or bad, of long-term use of the study treatment, faricimab, on patients with nAMD. If you take part in this clinical trial, you will receive faricimab.

    How do I take part in this clinical trial?

    To be able to take part in this clinical trial, you must have previously participated in and completed either Study GR40306 (also known as TENAYA) or GR40844 (also known as LUCERNE), without stopping the study treatment or the trial.

    If you have other conditions or need to take any other medications, you may not be able to take part.

    If you think this clinical trial may be suitable for you and would like to take part, please talk to your doctor. If your doctor thinks that you might be able to take part in this clinical trial, he/she may refer you to the closest clinical trial doctor. They will give you all the information you need to make your decision about taking part in the clinical trial. You can also find the clinical trial locations on this page.

    You will have some further tests to make sure you will be able to take the treatments given in this clinical trial. Some of these tests or procedures may be part of your regular medical care. They may be done even if you do not take part in the clinical trial. If you have had some of the tests recently, they may not need to be done again.

    Before starting the clinical trial, you will be told about any risks and benefits of taking part in the trial. You will also be told what other treatments are available so that you may decide if you still want to take part. 

    While taking part in the clinical trial, women (who are not currently pregnant but can become pregnant) will need to either not have heterosexual intercourse or take contraceptive medication for safety reasons. Women must not donate eggs while taking part in the clinical trial. 

    What treatment will I be given if I join this clinical trial?

    This clinical trial is split into two parts. 

    In Part 1 (the masked phase), everyone who joins this clinical trial will be given faricimab as an injection into the study eye. You will have study visits every four weeks for roughly 12 weeks but how often you receive injections will vary, depending on the condition of your eye. If a faricimab injection is not scheduled at a particular visit, you will have a “sham” treatment designed to feel like a real injection instead (an empty syringe without a needle will be pressed against your numbed eye).

    Neither you nor your clinical trial doctor will know whether you are receiving faricimab or sham treatment at each visit. However, your clinical trial doctor can find out how often you are receiving study treatment if your safety is at risk. 

    In Part 2 (the open-label phase), you will only have study visits when you need a faricimab injection. You will receive faricimab either every 8, 12 or 16 weeks, depending on the condition of your eye.

    How often will I be seen in follow-up appointments and for how long?

    You will be given the study treatment, faricimab, for roughly 2 years. You are free to stop this treatment at any time. While being given treatment, you will still be seen regularly by the clinical trial doctor. These hospital visits will include checks to see how you are responding to the treatment and to monitor any side effects that you may be having. 

    What happens if I am unable to take part in this clinical trial?

    If this clinical trial is not suitable for you, you will not be able to take part. Your doctor will suggest other clinical trials that you may be able to take part in or other treatments that you can be given. You will not lose access to any of your regular care.

    For more information about this clinical trial see the For Expert tab on the specific ForPatient page or follow this link to ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT04777201

    Trial-identifier: NCT04777201

    Study Summary

    This main long-term extension study is designed to evaluate the long-term safety and tolerability of faricimab 6 milligrams (mg) administered by intravitreal injection at a personalized treatment interval (PTI) to participants with neovascular age-related macular degeneration (nAMD) who enrolled in and completed one of the Phase III studies: GR40306 (NCT03823287) or GR40844 (NCT03823300), also referred to as the parent studies. Eligible patients who consent to participate in this main study will be enrolled upon completion of the end-of-study visit in the parent study. Additionally, there is a substudy that is being conducted. The aim of this substudy is to evaluate the impact of intravitreal faricimab on the health of the corneal endothelial cells in the study eyes of patients with nAMD to fulfill a U.S. Food and Drug Administration (FDA) post-marketing requirement. The fellow eyes of the same enrolled participants in the substudy will serve as the controls.

    Hoffmann-La Roche Sponsor
    Phase 3 Phase
    NCT04777201, GR42691, 2020-004523-16 Trial Identifier
    Faricimab, Sham Procedure Treatments
    Neovascular Age-related Macular Degeneration Condition
    Official Title

    A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Patients With Neovascular Age-Related Macular Degeneration (AVONELLE-X)

    Eligibility Criteria

    All Gender
    ≥50 Years Age
    No Healthy Volunteers
    Inclusion Criteria

    Inclusion Criteria for the Main Study:

    • Previous enrollment in and completion of Study GR40306 (NCT03823287) or Study GR40844 (NCT03823300), without study or study drug discontinuation
    • For women of childbearing potential: agreement to remain abstinent or use contraception, and agreement to refrain from donating eggs. Women must remain abstinent or use contraceptive methods with a failure rate of < 1% per year during the treatment period and for 3 months after the final dose of faricimab. Women must refrain from donating eggs during the same period.

    Inclusion Criteria for the Substudy:

    • In addition to all inclusion criteria specified in the main Study GR42691, participants in the Substudy must meet the following criteria:
    • Sign an informed consent form for the Substudy
    • Must be able to participate for at least 48 weeks in the Substudy and have at least the first visit while enrolled in the main Study GR42691
    • A difference of <10% in corneal endothelial cell density at screening between the two eyes as measured by specular microscopy and determined by the independent reading center
    Exclusion Criteria

    Exclusion Criteria for the Main Study:

    • Pregnant or breastfeeding, or intending to become pregnant during the study or within 3 months after the final dose of faricimab
    • Presence of other ocular diseases that give reasonable suspicion of a disease or condition that contraindicates the use of faricimab, that might affect interpretation of the results of the study or that renders the patient at high risk for treatment complications
    • Presence of other diseases, metabolic dysfunction, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of faricimab and that might affect interpretation of the results of the study or that renders the patient at high risk of treatment complications
    • History of a severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the faricimab injections, study-related procedure preparations, dilating drops, or any of the anesthetic and antimicrobial preparations used by a patient during the study
    • Requirement for continuous use of any medications or treatments indicated as prohibited therapy

    Exclusion Criteria for the Substudy:

    In addition to the exclusion criteria specified in the main Study GR42691, patients will be excluded from this substudy if they meet any of the following exclusion criteria:

    • Prior and/or current administration of faricimab in the fellow (non-study) eye
    • Prior administration of brolucizumab in the fellow (non-study) eye

    Exclusion Criteria in Either Eye for the Substudy:

    • Corneal endothelial cell density ≤1500 cells/mm2 in either eye at screening as determined by the independent corneal reading center
    • Fuchs endothelial corneal dystrophy Grade ≥2
    • Previous ocular trauma (blunt or penetrating) and/or corneal endothelial cell damage, including from blunt or surgical trauma (including complicated cataract surgery resulting in complicated lens placement such as anterior chamber intraocular lens, sulcus intraocular lens, aphakia, etc.)
    • Any ocular condition that precludes obtaining an analyzable specular microscopy image
    • Active or history of corneal edema
    • Any active or history of corneal dystrophies, excluding Fuchs endothelial corneal dystrophy Grade <2
    • Active or history of iridocorneal endothelial syndrome
    • Active or history of pseudoexfoliation syndrome
    • Active or history of herpetic keratitis or kerato-uveitis (including herpes simplex virus and herpes zoster virus)
    • Intraocular laser therapy including selective laser trabeculoplasty, yttrium-aluminum garnet (YAG), prophylactic peripheral iridotomy within 1 year of screening, or YAG capsulotomy within 3 months of screening
    • Prior vitrectomy surgery, submacular surgery, or other surgical intervention for AMD
    • Prior pars plana vitrectomy surgery
    • Previous intraocular device implantation excluding intraocular lenses
    • Cataract surgery within 6 months of screening or planned for during the study
    • History of glaucoma-filtering surgery, tube shunts, or microinvasive glaucoma surgery. Other types of prior glaucoma surgery are allowed providing that the surgery occur more than 6 months before screening
    • Administration of topical Rho kinase inhibitors (e.g., Rhopressa eye drops) within 1 month prior to the screening visit
    • Contact lens wear in either eye within 2 months of screening
    • History of corneal transplantation, including partial-thickness corneal grafts (e.g., Descemet membrane endothelial keratoplasty, Descemet stripping endothelial keratoplasty)
    • Active or history of iridocorneal endothelial syndrome
    • Active or history of pseudoexfoliation syndrome

    About Clinical Research

    What is a clinical trial? Why should I consider taking part in a clinical trial? And why does Genentech conduct clinical trials?

    Find out now