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1 Study StatusRecruiting1 A study to look at how safe new treatment combinations are and how well they work for people with breast cancer that has spread to nearby tissues and cannot be removed with surgery, or has spread in the body
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer
- Cancer,
- Breast Cancer,
- Inoperable Breast Cancer,
- Breast Cancer Er-Positive,
- Locally Advanced or Metastatic Breast Cancer
- NCT04802759, CO42867, 2020-004889-19,2023-507495-48-00
2 Study StatusRecruiting2 A clinical trial to compare how effective and safe giredestrant plus pertuzumab and trastuzumab is compared to pertuzumab and trastuzumab with or without hormone therapy in people with locally advanced or metastatic breast cancer, with HER2 and oestrogen receptor positivity
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
- Cancer,
- Oncology,
- Breast Cancer,
- Locally Advanced or Metastatic Breast Cancer,
- Estrogen Receptor (ER)-Positive,
- HER2-Positive Breast Cancer
- NCT05296798, WO43571, 2022-500014-26-00
3 Study StatusActive, not recruiting3 A clinical trial to compare GDC-9545 with a doctor’s choice of hormonal therapy in people with advanced or metastatic breast cancer after previous treatment has not worked.
A Study Evaluating the Efficacy and Safety of GDC-9545 Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
- Cancer,
- Breast Cancer,
- Breast Cancer Er-Positive,
- Breast Cancer HER-2 Negative,
- Locally Advanced or Metastatic Breast Cancer,
- Estrogen Receptor (ER)-Positive
- NCT04576455, WO42312, 2020-001984-10
4 Study StatusActive, not recruiting4 A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)
- Cancer,
- Breast Cancer,
- Breast Cancer Er-Positive,
- Breast Cancer HER-2 Negative,
- Locally Advanced or Metastatic Breast Cancer,
- Estrogen Receptor (ER)-Positive
- NCT05306340, ML43171, 2022-000199-20,2023-506821-12-00
5 Study StatusActive, not recruiting5 A clinical trial to compare GDC-9545 plus palbociclib with letrozole plus palbociclib in people with oestrogen receptor-positive, HER2-negative breast cancer
A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)
- Cancer,
- Breast Cancer,
- Breast Cancer Er-Positive,
- Breast Cancer HER-2 Negative,
- Locally Advanced or Metastatic Breast Cancer
- NCT04546009, BO41843, 2020-000119-66,2023-506911-16-00