A Time to Cardiovascular Event Analysis Comparing Tocilizumab to Other Biologics in Patients With Rheumatoid Arthritis (RA)

  • Rheumatoid Arthritis
Trial Status:


This trial runs in
Trial Identifier:

NCT02797769 GA30048

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      The source of the below information is the publicly available website ClinicalTrials.gov. It has been summarised and edited into simpler language.

      The below information is taken directly from the publicly available website ClinicalTrials.gov within a week of any updates, and has not been edited.

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      Trial Summary

      This retrospective cohort study will analyze data from multiple large U.S. health insurance claims databases to compare use of tocilizumab to other biologic disease-modifying anti-rheumatic drugs (DMARDs) in real world patients with RA. Using the date of dispensing as the index date, the analysis will compute the time to first event for several cardiovascular outcomes.

      Hoffmann-La Roche Sponsor
      NCT02797769 , GA30048 Trial Identifier
      Other Biologics, Tocilizumab Treatments
      Rheumatoid Arthritis Condition
      Official Title

      Risk of Cardiovascular Events in Patients Using Tocilizumab as Compared With Other Biologics in Multiple Large Healthcare Databases

      Eligibility Criteria

      All Gender
      ≥18 Years Age
      No Healthy Volunteers
      Inclusion Criteria
      • At least 1 inpatient or 2 outpatient diagnoses of RA
      • Continuous medical/pharmacy coverage and full claims data available
      • At least 6 months of insurance plan enrollment prior to index date
      Exclusion Criteria
      • Nursing home residents
      • Human immunodeficiency virus (HIV)
      • Malignancy
      • Receipt of chemotherapy
      • End-stage renal disease, dialysis, or transplant
      • Use of rituximab
      • Recent cardiovascular event (includes MI, stroke, ACS, or HF) within 90 days prior to index date

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