Study to Explore the Mechanism of Acquired Immune Escape In Participants With Metastatic Cancer Progressing on CPI Therapy

  • Cancer
  • Tumor
  • Neoplasms
Please note that the recruitment status of the trial at your site may differ from the overall study status because some study sites may recruit earlier than others.
Trial Status:

Completed

This trial runs in
Cities
  • Arrington
  • Barcelona
  • Boston
  • London
  • New York
  • Pamplona
  • San Francisco
  • Seoul
  • St. Louis
  • Toulouse
  • Ulsan
Trial Identifier:

NCT03333655 ML40108

      Show trial locations

      The source of the below information is public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc.. It has been summarised and edited into simpler language. For more information about this clinical trial see the For Expert tab on the specific ForPatients page or follow these links to https://clinicaltrials.gov and/or https://euclinicaltrials.eu and/or https://www.isrctn.com.

      The below information is taken directly from public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc., and has not been edited.

      Results Disclaimer

      Trial Summary

      The purpose of this study is to identify mechanisms associated with acquired immune escape by comparing baseline and at-progression tissue samples from participants who derive clinical benefit from CPI treatment of metastatic cancer or hematologic malignancies.

      Hoffmann-La Roche Sponsor
      Phase 4 Phase
      NCT03333655, ML40108 Trial Identifier
      Biopsy Treatments
      Neoplasms Condition
      Official Title

      A Multicenter Study to Explore the Mechanism of Acquired Immune Escape In Patients With Metastatic Cancer Progressing on Checkpoint Inhibitor Therapy

      Eligibility Criteria

      All Gender
      ≥ 18 Years Age
      No Healthy Volunteers
      Inclusion Criteria
      • Response assessment of complete response (CR), partial response (PR), or long-term stable disease (SD) for >6 months with a cancer immunotherapy treatment for metastatic cancer or hematologic malignancies either through a marketed CPI or through participation in a Roche/Genentech CPI clinical trial.
      • Availability of tissue sample.
      Exclusion Criteria
      • Pregnant, lactating, or intending to become pregnant during the study.
      • Participants receiving CPI treatment as part of a non-Roche/Genentech clinical trial.

      For the latest version of this information please go to www.forpatients.roche.com

       

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