A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (VANILLA)

A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (ASD)

  • Neurodevelopmental Disorder
  • Autism Spectrum Disorder
Please note that the recruitment status of the trial at your site may differ from the overall study status because some study sites may recruit earlier than others.
Trial Status:

Completed

This trial runs in
Cities
  • Baltimore
  • Bellevue
  • Bothell
  • Bronx
  • Centennial
  • Chicago
  • Cincinnati
  • Cleveland
  • Decatur
  • Delray Beach
  • Durham
  • Lexington
  • Minneapolis
  • Nashville
  • New Haven
  • New York
  • Oakland Park
  • Orangeburg
  • Orlando
  • Phoenix
  • Pittsburgh
  • Rockville
  • Sacramento
  • San Antonio
  • San Diego
  • San Francisco
  • Santa Ana
  • Seattle
  • Stanford
Trial Identifier:

NCT01793441 2012-005597-55 BP28420

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      The source of the below information is public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc.. It has been summarised and edited into simpler language. For more information about this clinical trial see the For Expert tab on the specific ForPatients page or follow these links to https://clinicaltrials.gov and/or https://euclinicaltrials.eu and/or https://www.isrctn.com.

      The below information is taken directly from public registry websites such as ClinicalTrials.gov, EuClinicalTrials.eu, ISRCTN.com, etc., and has not been edited.

      Results Disclaimer

      Trial Summary

      This multi-center, randomized, double-blind, parallel group, placebo-controlled, proof of concept study will investigate the efficacy and safety of RG7314 in adult participants with ASD. In Stage I of the study, participants will be randomized in 2:1 to receive daily oral doses of 1.5 milligrams (mg) RG7314 or placebo for 12 weeks. After an independent safety review, the study may proceed to Stage II. In Stage II of the study, additional participants will be randomized in 2:1 to receive daily oral doses of 4 mg RG7314 or placebo for 12 weeks. After an independent safety review, Stage III will be started wherein additional participants will be randomized in 2:1 to receive daily oral doses of 10 mg RG7314 or placebo for 12 weeks. During Stage III, safety will be reviewed by independent safety review twice and if no safety signal is observed, then additional participants will be randomized in 1:1:1 either to receive 1.5 milligrams per day (mg/day) or 10 mg/day RG7314 orally or placebo for 12 weeks in Stage IV.

      Hoffmann-La Roche Sponsor
      Phase 2 Phase
      NCT01793441,BP28420,2012-005597-55 Trial Identifier
      Placebo, RG7314 Treatments
      Autism Spectrum Disorder Condition
      Official Title

      A Multi-Center, Randomized, Double-Blind, 12-Week, Parallel Group, Placebo-Controlled Proof of Concept Study to Investigate the Efficacy and Safety of RG7314 in Individuals With Autism Spectrum Disorders (ASD)

      Eligibility Criteria

      Male Gender
      ≥18 Years & ≤ 45 Years Age
      No Healthy Volunteers
      Inclusion Criteria
      • Participants meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for ASD and Tenth Revision of the International Classification of Diseases and Related Health Problems (ICD-10) criteria for Autism diagnosis
      • SRS-2 (T-score) greater than or equal to (>/=) 66
      • CGI-S >/=4 (moderately ill)
      • Participants have an Intelligence Quotient (IQ) >/=70 (Wechsler Abbreviated State of Intelligence)
      • A body mass index (BMI) between 18 to 40 kilograms per square meter (kg/m^2) inclusive
      • Language, hearing and vision compatible with the study measurements as judged by the investigator
      • Lives with (or has substantial periods of contact with) a caregiver who is willing and able to attend visits when required, oversee the participant's compliance with protocol-specified procedures and study medication dosing, and report on the participant's status via completion of study assessments. Any period of absence must be covered by another caregiver. Non-cohabitating caregiver(s) must spend sufficient time with the participant so that, in the opinion of the investigator, the caregiver(s) can reliably assess participant's mental status, activities and behavior.
      Exclusion Criteria
      • Alcohol and/or substance abuse/dependence during the last 12 months
      • A significant risk for suicidal behavior, in the opinion of the investigator
      • Systolic blood pressure greater than (>) 140 or less than (<) 90 millimeters of mercury (mm Hg), and diastolic blood pressure >90 or less than (<) 50 mm Hg
      • Resting pulse rate >90 or <40 beats per minute
      • Use of prohibited medications or herbal remedies within 2 weeks prior to randomization, or 5 half-lives (whichever is longer)
      • Initiation of a new major change in psychological intervention within 4 weeks prior to randomization. Minor changes in ongoing treatment are not considered significant
      • Participation in an investigational drug or device study within 60 days prior to randomization

      For the latest version of this information please go to www.forpatients.roche.com

       

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